INHIBITING EZH2 TARGETS ATYPICAL TERATOID RHABDOID TUMOR BY TRIGGERING VIRAL MIMICRY VIA BOTH RNA AND DNA SENSING PATHWAYS

Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways

Abstract Inactivating mutations in SMARCB1 confer an oncogenic dependency on EZH2 in atypical teratoid rhabdoid tumors (ATRTs), but the underlying mechanism has not been Anti-Fatigue Mats fully elucidated.We found that the sensitivity of ATRTs to EZH2 inhibition (EZH2i) is associated with the viral mimicry response.Unlike other epigenetic therapies

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Ultrasound for identification of pleural fluid in pneumonia

It can be difficult to definitively differentiate between pleural effusion and empyema versus infiltrate alone on plain chest radiographs of patients.However, this is a clinically important distinction that drives optimal therapy, as large fluid collections are unlikely to resolve with antibiotic therapy alone and usually require drainage.Case repo

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Multi-version consolidation method for block-level backup data

Historical version backup data query efficiency was dependent on the version chain length in a multi-version backup data storage system.A novel block-level backup data multi-version consolidation method was presented for this SexFlesh problem.Any version of a historical full system snapshot could be generated within the incremental backup data vers

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